Endocrine Abstracts

Introduction: Insulin-like growth factor-1 (IGF-I), the main growth factor associated with GH secretion, directly opposes endothelial dysfunction and limit early atherosclerosis by favoring nitric oxide production, promoting insulin sensitivity and preventing postprandial dyslipidemia. A low serum IGF-I level has been reported in patients with OSA syndrome and might be one of the mechanisms underlying cardio-metabolic risks in OSA patients. IGF-1 levels were evaluated in a lar...

Introduction: Acromegaly is a rare disease (estimated prevalence 40–125 cases per million) resulting from GH/IGF1 hypersecretion, mostly by pituitary adenomas. SAS has a prevalence of up to 80% in acromegalic patients. The high frequency of acromegaly-related comorbidities and delayed diagnosis although effective treatments exist, make it necessary a screening of acromegaly in at risk populations.Aim: In a national multicenter study, to determine th...